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1.Flexible synthesis of polyfunctionalised 3-fluoropyrroles

Author:Cogswell, TJ;Donald, CS;Marquez, R


Abstract:An efficient and selective approach for the synthesis of polyfunctionalised 3-fluoropyrroles has been developed starting from commercial aldehydes. The methodology is concise, efficient and allows for the modular and systematic assembly of polysubstituted 3-fluoropyrroles. This synthesis provides an alternative and highly convergent strategy for the generation of these chemically and biologically important units.

2.Permafrost Degradation Leads to Biomass and Species Richness Decreases on the Northeastern Qinghai-Tibet Plateau

Author:Jin, XY;Jin, HJ;Wu, XD;Luo, DL;Yu, S;Li, XY;He, RX;Wang, QF;Knops, JMH


Abstract:Degradation of permafrost with a thin overlying active layer can greatly affect vegetation via changes in the soil water and nutrient regimes within the active layer, while little is known about the presence or absence of such effects in areas with a deep active layer. Here, we selected the northeastern Qinghai-Tibet Plateau as the study area. We examined the vegetation communities and biomass along an active layer thickness (ALT) gradient from 0.6 to 3.5 m. Our results showed that plant cover, below-ground biomass, species richness, and relative sedge cover declined with the deepening active layer, while the evenness, and relative forb cover showed a contrary trend. The vegetation indices and the dissimilarity of vegetation composition exhibited significant changes when the ALT was greater than 2.0 m. The vegetation indices (plant cover, below-ground biomass, evenness index, relative forb cover and relative sedge cover) were closely associated with soil water content, soil pH, texture and nutrient content. Soil water content played a key role in the ALT-vegetation relationship, especially at depths of 30-40 cm. Our results suggest that when the ALT is greater than 2.0 m, the presence of underlying permafrost still benefits vegetation growth via maintaining adequate soil water contents at 30-40 cm depth. Furthermore, the degradation of permafrost may lead to declines of vegetation cover and below-ground biomass with a shift in vegetation species.

3.Computational intelligence and metaheuristic algorithms with applications.

Author:Yang Xin-She; Chien Su Fong; Ting Tiew On


4.Identification of the UDP-glucose-4-epimerase required for galactofuranose biosynthesis and galactose metabolism in A. niger

Author:Park Joohae; Tefsen Boris; Arentshorst Mark; Lagendijk Ellen; van den Hondel Cees Amjj; van Die Irma; Ram Arthur Fj

Source:Fungal biology and biotechnology,2014,Vol.1

Abstract:Galactofuranose (Gal;In this study, we screened a collection of cell wall mutants with an induced expression of ;By using a classical mutant screen and whole genome sequencing of a new Gal

5.Follow-up study on pulmonary function and radiological changes in critically ill patients with COVID-19

Author:Zha, L;Shen, Y;Pan, LL;Han, MF;Yang, G;Teng, XB;Tefsen, B


6.Medical applications of microwave imaging.

Author:Wang Zhao; Lim Eng Gee; Tang Yujun; Leach Mark


Abstract:Ultrawide band (UWB) microwave imaging is a promising method for the detection of early stage breast cancer, based on the large contrast in electrical parameters between malignant tumour tissue and the surrounding normal breast-tissue. In this paper, the detection and imaging of a malignant tumour are performed through a tomographic based microwave system and signal processing. Simulations of the proposed system are performed and postimage processing is presented. Signal processing involves the extraction of tumour information from background information and then image reconstruction through the confocal method delay-and-sum algorithms. Ultimately, the revision of time-delay and the superposition of more tumour signals are applied to improve accuracy.

7.In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy

Author:Al-Mansoori Layla; Bashraheel Sara S; Qahtani Alanod D Al; O'Connor C David; Elsinga Philip; Goda Sayed K


Abstract:The sequence asparagine-glycine arginine (NGR), flanked by Cysteine (Cys) residues so as to form a disulfide-bridge (CNGRC), has previously been found to target and bind specifically to aminopeptidase N (APN), which is highly expressed on the surface of tumor cells. The goal of this study was to develop and evaluate the potential of fusion proteins carrying the CNGRC sequence linked to the enzyme carboxypeptidase G2 (CPG2) for targeted cancer therapy. We refer to this strategy as ligand-directed enzyme prodrug therapy (LDEPT). We constructed two forms of the CNGRC-CPG2 fusions, containing one or two copies of the cyclic NGR motif and designated CNGRC-CPG2 (X-CPG2) and CNGRC-CPG2-CNGRC (X-CPG2-X), respectively.

8.Increased Precipitation Shapes Relationship between Biochemical and Functional Traits of Stipa glareosa in Grass-Dominated Rather than Shrub-Dominated Community in a Desert Steppe

Author:Hu, Y;Zuo, XA;Yue, P;Zhao, SL;Guo, XX;Li, XY;Medina-Roldan, E


Abstract:Understanding the effects of precipitation variations on plant biochemical and functional traits is crucial to predict plant adaptation to future climate changes. The dominant species, Stipa glareosa, plays an important role in maintaining the structure and function of plant communities in the desert steppe, Inner Mongolia. However, little is known about how altered precipitation affects biochemical and functional traits of S. glareosa in different communities in the desert steppe. Here, we examined the responses of biochemical and functional traits of S. glareosa in shrub- and grass-dominated communities to experimentally increased precipitation (control, +20%%, +40%%, and +60%%). We found that +40%% and +60%% increased plant height and leaf dry matter content (LDMC) and decreased specific leaf area (SLA) of S. glareosa in grass community. For biochemical traits in grass community, +60%% decreased the contents of protein and chlorophyll b (Cb), while +40%% increased the relative electrical conductivity and superoxide dismutase. Additionally, +20%% increased LDMC and malondialaenyde, and decreased SLA and protein in shrub community. Chlorophyll a, Cb, carotenoids, protein and superoxide dismutase in the grass community differed with shrub community, while +60%% caused differences in SLA, LDMC, leaf carbon content, malondialaenyde and peroxidase between two communities. The positive or negative linear patterns were observed between different functional and biochemical traits in grass- rather than shrub-community. Soil water content explained changes in some biochemical traits in the grass community, but not for functional traits. These results suggest that increased precipitation can affect functional traits of S. glareosa in the grass community by altering biochemical traits caused by soil water content. The biochemical and functional traits of S. glareosa were more sensitive to extreme precipitation in grass- than shrub-community in the desert steppe. Our study highlights the important differences in adaptive strategies of S. glareosa in different plant communities at the same site to precipitation changes.

9.Chances and challenges in China

Author:Tefsen Boris

Source:Protein & Cell,2016,Vol.7

Abstract:So there I was, 35 years old and at the crossroads of my scientific career. The current academic system in the Netherlands, like in many other places around the world (Powell, 2015), is not designed to have scientists staying in a postdoc position forever. So, you are either deemed good enough to become a permanent staff member, or you have to leave academia at some point and try your luck in a pharmaceutical company or elsewhere. I had not succeeded in the former, but I also did not want to do the latter, so I took a less threaded path and headed to China.

10.Impacts of land use changes on soil properties and processes.

Author:Paz González Antonio; de Abreu Cleide Aparecida; Tarquis Ana Maria; Medina-Roldán Eduardo


11.Synthesis of TiO2 modified self-assembled honeycomb ZnO/SnO2 nanocomposites for exceptional photocatalytic degradation of 2,4-dichlorophenol and bisphenol A

Author:Ali, W;Ullah, H;Zada, A;Muhammad, W;Ali, S;Shaheen, S;Alamgir, MK;Ansar, MZ;Khan, ZU;Bilal, H;Yap, PS


Abstract:In this study, we have successfully synthesized honeycomb-like self-assembled structure of TiO2 modified ZnO/SnO2 nanostructure via co-precipitation method with exceptional high degradation activities for 2,4-dichlorophenol (2,4-DCP) and bisphenol A (BPA) pollutants. The as-prepared samples were calcined in tube furnace at high elevated temperature (700, 800 and 900 degrees C) for 1 h. Among the TiO2 modified samples, ZST10-700 showed higher charge separation as demonstrated from surface photovoltage spectroscopy, photoluminance and electrochemical curve. Surface morphology, crystallinity, optical property and different functional groups in the samples were determined with SEM, EDX, XRD, UV-Vis DRS and FTIR, respectively. Interestingly, 72%% and 58%% photocatalytic degradation efficiencies were achieved with optimized ZST10-700 for 2,4-DCP and BPA, respectively. In comparison, the pure ZS-700 only showed 36%% and 29%% photocatalytic degradation efficiencies, respectively. The improved photocatalytic degradation efficiencies of the optimized ZST10-700 are mainly due to improved charge separation and prolonged charge lifetime. It was further verified that by increasing calcination temperature, the photocatalytic activity decreased, and this is attributed to the formation of photo-inactive phases like Zn2SnO4 and ZnTiO3. We believe that this work will provide an effective strategy to construct ternary heterojunction for the elimination of pollutants. (C) 2020 Elsevier B.V. All rights reserved.

12.The Impact of Microplastic Particles on Population Dynamics of Predator and Prey: Implication of the Lotka-Volterra Model

Author:Huang, Q;Lin, YY;Zhong, QY;Ma, F;Zhang, YX


Abstract:Microplastic particles are widely distributed in a variety of ecosystems and can be transferred to predators along a food chain after being ingested by prey. However, how microplastic particles affect prey and predator populations is not fully understood. In this study, using the Lotka-Volterra model, we theoretically investigated predator-prey population dynamics in terms of toxicological response intensity (strength to population growth rate) to microplastic particles, and examined the negative effects on prey feeding ability and predator performance due to microplastic particles. Results of numerical simulations indicate the critical properties of the predator-prey system in response to microplastic particles: (i) predators are more vulnerable than prey under exposure to microplastic particles; (ii) the effect of microplastic particles on prey and predator population growths can be negligible when toxicological response intensities of prey and predator are small; (iii) this system is prey dependent for predator functional response, whose stability highly relies on the density of prey; (iv) the reduced feeding capacity of prey and predator induced by microplastic particles does not significantly affect the population dynamics of the predator-prey system. Moreover, our analysis suggests that dynamic Lotka-Volterra models can play a vital role in predicting ecological impacts of microplastic particles on predator-prey population dynamics.
Total 12 results found
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