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1.A 9,9 '-spirobi[9H-fluorene]-cored perylenediimide derivative and its application in organic solar cells as a non-fullerene acceptor

Author:Yi, JD;Wang, YL;Luo, Q;Lin, Y;Tan, HW;Wang, HY;Ma, CQ


Abstract:A structurally non-planar molecule (SBF-PDI4) with a 9,9'-spirobi[9H-fluorene] (SBF) core and four perylenediimides (PDIs) at the periphery was designed, synthesized and characterized. This compound shows a low-lying LUMO energy level of -4.11 eV, which is similar to that of PCBM, but with intensive light absorption ability in the range 450-550 nm. A high power conversion efficiency (PCE) of 5.34%% was obtained for a solution processed bulk heterojunction solar cell (BHJSC) using SBF-PDI4 as the electron acceptor and a low-band gap polymer poly[[4,8-bis[5-(2-ethylhexyl)thiophene-2-yl]benzo[1,2-b: 4,5-b']dithiophene-2,6-diyl][3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl]] (PTB7-Th) as the electron donor. These results demonstrate that PDI derivatives with a three dimensional molecular structure could serve as high performance electron acceptors in BHJSCs.

2.Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation

Author:Spry, C;Sewell, AL;Hering, Y;Villa, MVJ;Weber, J;Hobson, SJ;Harnor, SJ;Gul, S;Marquez, R;Saliba, KJ


Abstract:Survival of the human malaria parasite Plasmodium falciparum is dependent on pantothenate (vitamin B-5), a precursor of the fundamental enzyme cofactor coenzyme A. CJ-15,801, an enamide analogue of pantothenate isolated from the fungus Seimatosporium sp. CL28611, was previously shown to inhibit P. falciparum proliferation in vitro by targeting pantothenate utilization. To inform the design of next generation analogues, we set out to synthesize and test a series of synthetic enamide-bearing pantothenate analogues. We demonstrate that conservation of the R-pantoyl moiety and the trans-substituted double bond of CJ-15,801 is important for the selective, on-target antiplasmodial effect, while replacement of the carboxyl group is permitted, and, in one case, favored. Additionally, we show that the antiplasmodial potency of CJ-15,801 analogues that retain the R-pantoyl and trans-substituted enamide moieties correlates with inhibition of P. falciparum pantothenate kinase (PfPanK)-catalyzed pantothenate phosphorylation, implicating the interaction with PfPanK as a key determinant of antiplasmodial activity. (C) 2017 Elsevier Masson SAS. All rights reserved.

3.Facile synthesis and efficient electrochemiluminescence of a readily accessible pyridopyrimidine

Author:Zhang, RZ;Tong, F;Yang, LQ;Adsetts, JR;Yan, TH;Wang, RY;Ding, ZF;Wang, HB


Abstract:Through a facile one-pot three-component reaction and a subsequent acetylation strategy, a novel greenish-blue fluorescent 4-imino-4H-pyrido[1,2-a] pyrimidine-3-carbonitrile (IPPC) was synthesized. Electrochemiluminescence (ECL) of IPPC was firstly found to produce efficient emission at 500 nm with reducing coreactants. Its very similar ECL and PL spectra suggest that ECL production is mainly from the monomeric excited states.
Total 3 results found
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