Elevated serum uric acid, hyperuricaemia and dietary patterns among adolescents in mainland China

Zhou, H;Ma, ZF;Lu, YM;Du, YY;Shao, J;Wang, LY;Wu, Q;Pan, BY;Zhu, WX;Zhao, QH;Wei, H

[Zhou, Hang; Lu, Yiming; Du, Yanyan; Shao, Jian; Wang, Liya; Wu, Qin; Zhao, Qihua; Wei, Hua] Yangzhou Univ, Clin Med Coll, Yangzhou 225009, Jiangsu, Peoples R China.
[Zhou, Hang; Du, Yanyan; Shao, Jian; Wang, Liya; Zhao, Qihua; Wei, Hua] Northern Jiangsu Peoples Hosp, Dept Clin Nutr, Yangzhou 225001, Jiangsu, Peoples R China.
[Ma, Zheng Feei] Xian Jiaotong Liverpool Univ, Dept Hlth & Environm Sci, Suzhou, Jiangsu, Peoples R China.
[Lu, Yiming] Northern Jiangsu Peoples Hosp, Dept Orthoped, Yangzhou, Jiangsu, Peoples R China.
[Wu, Qin] Northern Jiangsu Peoples Hosp, Dept Rheumatol & Immunol, Yangzhou, Jiangsu, Peoples R China.
[Pan, Binyu] First Peoples Hosp Wujiang Dist, Dept Clin Nutr, Suzhou, Jiangsu, Peoples R China.
[Zhu, Wenxi] Yangzhou Emergency Med Ctr, Yangzhou, Jiangsu, Peoples R China.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Volume:33 Issue:4Pages:487-493

DOI:10.1515/jpem-2019-0265

Publication Year:2020

JCR:Q3;Q4

CAS JCR:4区

ESI Discipline:CLINICAL MEDICINE

Latest Impact Factor:1.634

Document Type:Journal Article

Identifier:http://hdl.handle.net/20.500.12791/002857

Abstract

Background: Elevated serum uric acid concentrations have been associated with metabolic syndrome. However, only limited information is available on the prevalence of hyperuricaemia in adolescents. Therefore, the aim of our cross-sectional study was to study the prevalence of hyperuricaemia and dietary patterns in adolescents aged 13-16 years living in Yangzhou, China. Methods: Adolescents were asked to complete a 20-item food frequency questionnaire (FFQ) and provide an overnight fasting finger-prick sample. Principal component analysis (PCA) with varimax rotation was used to derive the dietary patterns that might be associated with high uric acid concentrations. Results: A total of 1070 adolescents were recruited. Of these, 53.6%% (n = 574) were females, and 58.5%% (n = 625) were within the normal body mass index (BMI) range. The males had a significantly higher serving size and frequency in their weekly food consumption, including meat, poultry, Chinese cereal staple foods and Western-style fast foods, than the females (all p < 0.02). The overall mean serum uric acid concentration and prevalence of hyperuricaemia were 368.6 +/- 114.5 mu mol/L and 37.9%%, respectively. The prevalence of hyperuricaemia was 4.633 times greater among the participants who were overweight and obese than among those who were underweight. On the other hand, the prevalence of hyperuricaemia was 0.694 times lower among the participants who had normal weight than those who were underweight. Conclusions: The prevalence of hyperuricaemia was relatively high in Chinese adolescents. The prevention of hyperuricaemia measures should be strengthened in adolescents to effectively control for obesity and gout, which tend to persist into adulthood.

Keywords

dietary pattern uric acid adolescents purine hyperuricaemia

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